Functional, Behavioral, and Histological Changes Induced by Transient Global Cerebral Ischemia in Rats: Effects of Cinnarizine and Flunarizine
نویسندگان
چکیده
منابع مشابه
Time-dependent changes in cerebral choline and acetylcholine induced by transient global ischemia in rats.
We occluded the carotid and vertebral arteries of 12 rats for 15 minutes to measure the brain concentrations of choline and acetylcholine and cerebral blood flow at the end of the ischemic period or 15, 30, or 150 minutes after circulation was reestablished. The animals were sacrificed with microwave radiation focused to the head immediately after a brief infusion of [14C]iodoantipyrine with ra...
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Introduction: Ethanol is considered as an effective agent in reducing brain stroke injury. In this study, we assessed the effects of modafinil along with ethanol as a combination therapy on behavioral function in Wistar rats. Methods: The right Middle Cerebral Artery Occlusion (MCAO) was performed and the rats were divided into nine groups (n=8 per group). The animal groups in this study were ...
متن کاملParkinsonism, tremor, and depression induced by cinnarizine and flunarizine.
Comment Both these patients were positive for HIV antibody and had a clinical and radiological presentation suggestive of P carinni pneumonia that responded to treatment; thus the criteria fbr a diagnosis of AIDS were satisfied. ' In case 2 the diagnosis was complicated by the previous amiodarone treatment, though pneumonitis induced by amiodarone is unusual at a daily dosage less than 400 mg.2...
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Introduction: Ischemic stroke is one of the leading causes of morbidity and mortality worldwide. Neuroprotective strategies were reported to attenuate cognitive deficits after ischemic incidents. Here we studied the neuroprotective potential of chrysin in a rat model of cerebral Ischemia/Reperfusion (I/R) in the presence or absence of Estrogen Receptors (ERs). Methods: Adult male Wistar rats w...
متن کاملFlunarizine and cinnarizine-induced parkinsonism: a historical and clinical analysis.
BACKGROUND Drug-Induced Parkinsonism (DIP) represents the second leading cause of Parkinsonism (PK) in several countries. Flunarizine and cinnarizine are some of the most common drugs that cause DIP. This paper reviews the first description of Flunarizine and Cinnarizine-Induced Parkinsonism (FCIP), as well as the subsequent literature, emphasizing epidemiological, clinical and diagnostic aspec...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1989
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1989.92